Yocell Biotechnology (Qingdao) Co., LTD

Antibody-conjugated drugs (ADCs) are novel tumor treatment drugs that possess both precise targeting and efficient killing capabilities. With advantages such as enhanced efficacy and reduced systemic toxicity, they have become a research hotspot. The tangential flow filtration (TFF) technology is widely used in the downstream process of ADC drugs, capable of efficiently removing organic impurities, coupling related impurities, and achieving buffer solution replacement. The ADC recovery rate exceeds 90%. This technology requires optimizing the process by controlling key parameters such as inlet and outlet pressure, flow rate, and pH. The core application lies in antibody concentration and desalination, product purification, and buffer solution replacement of ADC drugs, providing core support for the efficient preparation and stability of ADC drugs. Yocell's tangential flow system, through technological innovation, helps advance anti-tumor treatment towards precision and reliability.

Monoclonal antibody production relies on the long-term stable culture of mammalian cells such as CHO cells and HEK293 cells, which requires high requirements for sterility, parameter stability and contamination prevention and control of the reactor --- GMP stainless steel reactor adopts 316L medical grade stainless steel tank with mirror polishing and double mechanical sealing.

In the material processing stage of fields such as food, medicine, and bioengineering, "homogenization" is a key process that determines the quality and functionality of the product. It not only makes the particle size of the material more uniform and enhances its stability but also activates the biological activity of the effective components, endowing the product with higher market value. As the core equipment for achieving efficient homogenization, high-pressure homogenizers, with their outstanding technical performance, are becoming the "sharp weapon" for more and more enterprises to break through production bottlenecks and achieve quality upgrades.

Protein, as the material basis of life, is the main carrier of life activities. For downstream processes, new ligand purification technologies are constantly being developed, which can remove various impurities in complex protein samples more safely, economically and efficiently. This paper summarizes the research status, innovative applications and development prospects of medium materials with different ligands (including hydrophobic ligands, ion-exchange ligands, mixed-mode ligands and short peptide biomimetic ligands) and protein separation technologies (including polymer grafting technology and continuous column chromatography technology), with the aim of obtaining effective resources in the protein purification process and providing references for the development of downstream purification technologies.

In the field of life sciences, the research on exosomes has gradually become a hot topic, and its influence on people's lives is also multi-faceted. From the early detection of cancer to immune regulation, the application of exosomes has permeated all aspects of medical and health care. For instance, studies have found that exosomes can carry specific miRNAs for non-invasive diagnosis of cancer; they can also help treat inflammatory diseases by regulating the immune system.

The separation and purification of proteins is a complex process. Usually, different purification strategies are adopted based on the varying properties of proteins such as size, solubility, and charge. In this article, we will introduce the basic principles and practical applications of protein purification techniques.