Yocell Biotechnology (Qingdao) Co., LTD

Chimeric antigen receptor T-cell (CAR-T) therapy has achieved groundbreaking progress in cancer treatment, and lentiviral vectors (LVs), as core raw materials for gene delivery systems, are directly linked to the safety and cost-effectiveness of therapies through optimization of their downstream purification processes. This article systematically reviews the three major stages of LV downstream purification—clarification filtration, purification, and final polishing and sterilization—highlighting recent technological advances. It focuses on the application strategies of tangential flow filtration (TFF), analyzes the impact of membrane material selection and process parameter control on LV activity and recovery rate, and discusses challenges in scale-up production along with future research directions.

Microfluidization high-pressure homogenization technology can encapsulate astaxanthin into microscopic particles to produce a stable nanolipid formulation.

We have shipped a new fully automatic protein purification systems that have undergone rigorous factory calibration, quality testing and professional packaging for global research and biopharmaceutical clients.

Recently, Yocell successfully completed the shipping of three sets of equipment: the YC-Nano10 high-pressure homogenizer, the LE-1 manual liposome extruder and the LE-100 manual liposome extruder.

Recently, Yocell has successfully secured a tender for a set of YC-FLEX benchtop parallel bioreactors！

This article explores the application of biological fermentation in the pharmaceutical industry. Biological fermentation boasts economic, eco-friendly and scalable strengths, and has become a key technology for manufacturing antibiotics, vitamins and other major drugs. It covers three core production stages with corresponding professional supporting equipment, alongside testing and energy-saving devices to guarantee standardized and green production. With technological upgrades, biological fermentation will further drive pharmaceutical innovation and enjoys promising development prospects.