Yocell Biotechnology (Qingdao) Co., LTD

Yocell recently completed the shipment of a 10L & 30L dual-tank bioreactor system featuring independent parameter control and full aseptic structure.

High pressure microfluidization technology effectively addresses key bottlenecks in the preparation of coenzyme Q10 formulations while efficiently preserving biological activity. It serves as a preferred manufacturing process for high quality CoQ10 products.

Bioreactor off-gas refers to a collection of gaseous products generated by microorganisms or cells during metabolism and discharged from the reactor along with aeration gas. Variations in the concentrations of its components directly reflect substance transformation and energy metabolism within the culture system, serving as a core non-invasive, real-time online window to obtain physiological information in Process Analytical Technology (PAT).

Recently, our brand-new YC-MH06 High Pressure Microfluidization Homogenizer has completed full quality testing, professional packaging and official shipment, heading to our customer’s site smoothly.

Chimeric antigen receptor T-cell (CAR-T) therapy has achieved groundbreaking progress in cancer treatment, and lentiviral vectors (LVs), as core raw materials for gene delivery systems, are directly linked to the safety and cost-effectiveness of therapies through optimization of their downstream purification processes. This article systematically reviews the three major stages of LV downstream purification—clarification filtration, purification, and final polishing and sterilization—highlighting recent technological advances. It focuses on the application strategies of tangential flow filtration (TFF), analyzes the impact of membrane material selection and process parameter control on LV activity and recovery rate, and discusses challenges in scale-up production along with future research directions.

Microfluidization high-pressure homogenization technology can encapsulate astaxanthin into microscopic particles to produce a stable nanolipid formulation.