Yocell Biotechnology (Qingdao) Co., LTD

Chimeric antigen receptor T-cell (CAR-T) therapy has achieved groundbreaking progress in cancer treatment, and lentiviral vectors (LVs), as core raw materials for gene delivery systems, are directly linked to the safety and cost-effectiveness of therapies through optimization of their downstream purification processes. This article systematically reviews the three major stages of LV downstream purification—clarification filtration, purification, and final polishing and sterilization—highlighting recent technological advances. It focuses on the application strategies of tangential flow filtration (TFF), analyzes the impact of membrane material selection and process parameter control on LV activity and recovery rate, and discusses challenges in scale-up production along with future research directions.

Microfluidization high-pressure homogenization technology can encapsulate astaxanthin into microscopic particles to produce a stable nanolipid formulation.

This article explores the application of biological fermentation in the pharmaceutical industry. Biological fermentation boasts economic, eco-friendly and scalable strengths, and has become a key technology for manufacturing antibiotics, vitamins and other major drugs. It covers three core production stages with corresponding professional supporting equipment, alongside testing and energy-saving devices to guarantee standardized and green production. With technological upgrades, biological fermentation will further drive pharmaceutical innovation and enjoys promising development prospects.

Microfluidization high-pressure homogenization is a mainstream technology for preparing nano lipid carriers (liposome/nano emulsion). It can increase the encapsulation efficiency of Pro-Xylane to 85%~90%, control the particle size within 50~200 nm, and raise the transdermal rate by approximately 40%, which significantly enhances its stability and skin delivery efficiency.

Protein purification is a process that separates and purifies target proteins from complex mixtures by taking advantage of the differences in their physical and chemical properties. Its core objective is to obtain high-purity and highly active protein products, and it is a cornerstone technology in biological research and the biotechnology industry.

Extracellular polysaccharides found on the outermost layer of bacteria, such as capsular polysaccharides or micro capsular polysaccharides, are key virulence factors responsible for invasive bacterial infections. They also serve as the primary antigenic components in vaccines designed to prevent and control such infections.