Since the discovery of antisense nucleic acid and RNAi phenomenon, the mechanism advantages and broad targets of oligonucleotide drugs have attracted the attention of the pharmaceutical community, and by 2003, a number of companies dedicated to the development of RNAi drugs have been established, however, unmodified oligonucleotide drugs have not achieved the expected efficacy in clinical trials and caused immune-related toxicity. Big pharma companies exited RNAi around 2010.
The choice of stirrer type, stirring speed and aeration mode (jet/surface aeration) determines the fluid flow pattern in a conventional stirred tank bioreactor.
As animal cells are very different from microbial cells, there are strict requirements for in vitro culture, therefore it is important and urgent to develop new bioreactors based on the characteristics of animal cells.
High-pressure homogenizer equipped with the second-generation microfluidic diamond interactive chamber.
Notes on the use of centrifuges (important) & routine maintenance of the centrifuge
How to improve the dispersibility of carbon nanotubes has become an urgent problem to be solved.
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